The Ghana defender came on in the second half when Arsenal defeated his side Leicester City on Friday.
The Ghanaian international was introduced in the 72 minute when he came on to replace Shinji Okazaki.
In the game itself, Lacazette opened his Premier League goal account when he scored with less than a minute into the game from a header, but Okazaki drew the visitors level.
Jamie Vardy put Leicester City in the driving seat, but Arsenal came on level pegging on the stroke of half time.
Before Jamie Vardy restored Leicester City's lead with a brilliant header after the interval.
Arsene Wenger made two quick changes by introducing Aaron Ramsey and Olivier Giroud and it paid off when the former got the equaliser, before the latter scored the match winner in the late minutes.