A two-point conversion, via a Derek Carr pass to Michael Crabtree, saw the Raiders edge the Saints 35-34.
Aaron Rodgers, meanwhile, was in decent form for the Packers, throwing two touchdown passes in a 27-23 win over the Jacksonville Jaguars.
On a 13-game day, an incredible 10 were decided by a single score.
The New England Patriots held on for a 23-21 win over the Arizona Cardinals and the Detroit Lions claimed a 39-35 victory against the Indianapolis Colts.
The Tampa Bay Buccaneers overcame the Atlanta Falcons 31-24 and the Kansas City Chiefs rallied from behind to beat the San Diego Chargers 33-27 after overtime.
There were also wins for the Minnesota Vikings (over the Tennessee Titans), Philadelphia Eagles (Cleveland Browns), Cincinnati Bengals (New York Jets), Baltimore Ravens (Buffalo Bills), Houston Texans (Chicago Bears), Seattle Seahawks (Miami Dolphins) and New York Giants (Dallas Cowboys).
RODGERS, COOKS THE HIGHLIGHTS
Somehow, Packers quarterback Rodgers got rid of the ball with a guy pulling on him and, some way, Davante Adams caught it for a 29-yard touchdown just before half-time of Green Bay's win over the Jaguars.
Saints receiver Brandin Cooks absolutely torched Raiders cornerback Sean Smith in the third quarter of Sunday's loss. Cooks blew past Smith on a simple fly route up the sideline and raced 98 yards for a touchdown. It was just the 13th touchdown pass of 98 yards or more in NFL history and longest in Saints history. Cooks finished with six catches for 143 yards and two scores.
MORE IS LESS FOR TOP QBS
Three quarterbacks — New Orleans' Drew Brees, Indianapolis' Andrew Luck and Tampa Bay's Jameis Winston — threw four touchdowns, but Winston's Buccaneers were the only of the three who were victorious. Brees' and Luck's efforts were rendered moot by way of heartbreaking final-minute losses.
Carson Wentz's NFL career could not have gotten off to a better start. He went four-for-five on Philadelphia's opening series while leading a touchdown drive that ended with a perfectly placed 19-yard pass to Jordan Matthews in the corner of the end zone. Wentz finished 22 of 37 for 278 yards and two touchdowns.
BY THE NUMBERS
Buffalo's 11 first downs in Sunday's loss to the Ravens were their fewest in a game since October 7, 2012 against San Francisco (10). The Bills had 160 total yards on offense, their fewest in a game since tallying 145 yards in a 40-7 loss to Chicago on October 8, 2006.
Kansas City rallied from a 21-point deficit to beat the Chargers. It was the largest comeback victory in franchise history and tied for the third-largest blown lead in a losing game in San Diego's franchise history.
The Cincinnati Bengals won their first road game against the New York Jets since September 13, 1981. They had lost nine straight road games to the Jets prior to Sunday.
TWO CLOSE TO CALL
Raiders coach Jack Del Rio on going for two to beat the Saints: "I was thinking that we're here to win; let's win it right now."
Cooks on his record-setting 98-yard touchdown pass from Brees: "Drew and I, we just happened to be on the same page, thinking the same thing. He put a beautiful ball out there and all I had to do was lay out my hands and the ball was there."
Of Sunday's 13 games, 10 were decided by a single score, including three one-point games and two two-pointers. Including the Denver Broncos' 21-20 win over the Carolina Panthers, there were four one-point games on opening weekend for the first time in NFL history.