The agreement grants “unimpeded” access to the United States to deploy troops and military equipment in Ghana.
Many security analysts have said it constitutes a military, a move in sharp contrast to Ghana's foreign police.
The US embassy in Accra has denied the claim, saying the agreement, which has no termination clause, is just for one year and that $20 million will be invested in the Ghana army and police service.
The minority leader Haruna Iddrisu warned against ratifying the agreement because it has no signature.
He also noted that the military cooperation deal was not in the interest of Ghana, noting that the presence of US troops in Ghana could invite extremists to attack Ghana.
“We will not be part of the process to endorse this deal in its current form because it is not in our national interest,” he said as his side boycotted the proceedings.