Asked by the conservative Tasnim news agency if there was any plan to meet US Secretary of State Mike Pompeo, Zarif said: "No, there will be no meeting."
He said there were also no plans for a meeting with US officials on the sidelines of the UN General Assembly in New York next month, which both Iranian President Hassan Rouhani and his US counterpart Donald Trump are due to attend.
"On Trump's recent proposal (of talks), our official stance was announced by the president and by us. Americans are not honest and their addiction to sanctions does not allow any negotiation to take place," Zarif told Tasnim.
It was Iran's most explicit rejection of talks to date, after much speculation that economic pressure would force its leaders back to the table with Washington.
The US reimposed sanctions on Tuesday, following its withdrawal from the 2015 nuclear deal between Iran and major powers in May.
Zarif met repeatedly with then US secretary of state John Kerry during the agreement's negotiation and implementation.
Rouhani said last week that Iran "always welcomed negotiations" but that Washington would first have to demonstrate it can be trusted.
"If you're an enemy and you stab the other person with a knife and then you say you want negotiations, then the first thing you have to do is remove the knife."
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