The Belgium playmaker came off worst in a challenge with N'Golo Kante just two minutes into the second-half and hobbled off to be replaced by Phil Foden.
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De Bruyne injury concern for Man City ahead of PSG tie
Manchester City suffered a major injury scare just 11 days before the first leg of their Champions League semi-final against Paris Saint-Germain as Kevin De Bruyne was forced off with an ankle injury in Saturday's FA Cup semi-final against Chelsea.
De Bruyne down: Kevin De Bruyne (centre)had to be replaced with an ankle injury during Manchester City's FA Cup semi-final against Chelsea
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City reached the last four of the Champions League for the first time in five seasons under Pep Guardiola with victory over Borussia Dortmund on Wednesday.
However, the loss of De Bruyne would be a huge blow to City's hopes of winning European football's premier club competition for the first time.
PSG host the runaway Premier League leaders on April 28 with the return leg at the Etihad Stadium just six days later.
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