The Chile international saw his penalty saved in the 68th minute but he scored when the ball came back off goalkeeper Jonas Lossl.
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Sanchez opens Man Utd goalscoring account
Alexis Sanchez scored his first goal for new side Manchester United on Saturday on his first appearance at Old Trafford, netting the second against Huddersfield.
Sanchez, 29, joined United from Arsenal during the January transfer window, with Henrikh Mkhitaryan moving in the opposite direction.
The forward impressed in his first outing for Jose Mourinho's team in last week's FA Cup tie away to lowly Yeovil but was quiet in United's midweek defeat by Tottenham at Wembley.
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