He said this is because of what transpired between the two countries at the 2010 World Cup in South Africa.
We’ll fight to get our revenge against Uruguay – Mohammed Salisu
Black Stars and Southampton defender Mohammed Salisu has stated that Ghana will give its all in their final group game against Uruguay at the 2022 World Cup.
Asked about how he will approach Ghana's final group game against Uruguay in the 2022 World Cup, Salisu said it is an opportunity for them to seek revenge for Ghanaians.
"Ghanaians are looking forward to that game because we are going for revenge. I’m also looking forward to the game and I need to be with my country and fight for my country. I think I’m part of the revenge."
“When we played against Uruguay at the  World Cup, Ghana was the best team African team at that World Cup and that memory inspires me,” he told Southampton’s media team.
According to the Southampton defender, he still has memories of Ghana's painful exit from the 2010 World Cup and that will serve as additional motivation on December 2.
In the 2010 FIFA World Cup quarter-final clash between Ghana and Uruguay, Luis Saurez used his hand to prevent a goal-bound header from Dominici Adiyah which earned the Black Stars a late-minute penalty.
Unfortunately for Ghana, Asamoah Gyan could not convert from the spot.
Ghana then went on to lose 4-2 on penalties to Uruguay.