Kotoko were the only side that managed to beat Bechem United in the first round of the Ghana Premier League at Bechem, the visitors will seek revenge, while the hosts would want a repeat of the league results.
Bechem United have beefed up their squad with inclusion of Alfred Nelson, former skipper of Liberty Professionals, while the Porcupine Warriors also did good business in the second transfer window by getting the signature of the likes of Emmanuel Gyamfi, Emmanuel Osei, etc.
Dauda Mohammed is the top scorer for Kotoko, having scored 7 league goals, so a battle would be staged between him and Alfred Nelson.
Wa Rockets and Liberty Professionals on Saturday won their respective games to book their tickets to last four of the national knockout competition.
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Asante Kotoko last season reached the final of the MTN FA Cup, but lost 2-1 to Medeama at Essipong Sports Stadium.