The usually reliable George Ford missed six kicks at goal on Sunday, but England nevertheless had far too much for Wales.
England out-scored Wales by five tries to one to record a convincing 27-13 victory at Twickenham ahead of the teams' southern hemisphere tours.
Warren Gatland's men were quick out of the blocks at Twickenham on Sunday, opening up a 10-point lead inside 15 minutes as Dan Biggar added a penalty to a converted score from Rob Evans.
Wales, who lost skipper Dan Lydiate to an injury in the first half, still held a slender advantage at half-time, but the 2016 Six Nations and Grand Slam winners ran in 17 unanswered points in the second period.
England's margin of victory would have been even more comfortable had George Ford not endured a miserable day with the boot, the Bath fly-half missing six of his seven attempts at goal.
Ford's inaccuracy from the tee saw Eddie Jones' side, who play the first of three Tests with Australia on June 11, trailed 13-10 at the interval despite Luther Burrell and Anthony Watson crossing.
Ben Youngs cut through Wales' defence from the back of a lineout to put England ahead for the first time early in the second half, before a breakaway try from Jack Clifford, his first for England, was converted by Ford.
Marland Yarde - a controversial selection by Jones at the expense of Chris Ashton - rounded off the scoring, leaving Wales with much room for improvement ahead of their series against world champions New Zealand.
Experienced Wales centre Jamie Roberts told Sky Sports: "It was frustrating, we didn't come out in the second half.
"We didn't stay in it for 80 minutes. We've got two weeks to work on it before the first Test [in New Zealand]. We know the level we're at, and we know where we need to be."