According to reports, the player was 37-years-old.
The demise of the ex-Kotoko player was confirmed by his sister, Abigail Comfort Owusu on Facebook on Saturday, October 24.
She posted a collage of the former Tusker FC player with the inscription: "Fare thee, my brother."
According to a Ghanasoccernet report, Owusu had been bedridden for some time now after contracting an illness in Kenya.
Stephen Owusu also played for Accra Heart of Lions and Accra Celtics.