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Senanu picked up an injury during last Wednesday's 2-1 win over Zesco United at home.
He was stretchered off and had to be replaced by Habib Mohammed, a new signing.
According to reports, he will be out of action for weeks after undergoing a medical examination at the Kamfo Anokye Teaching Hospital.
Kotoko face Nkana FC on Sunday, 24 February 24 2019.
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