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Chelsea said in a statement on their website that the date of the match, February 23, and the kick-off time (2000 GMT) would remain the same.
The second leg is scheduled to take place at Stamford Bridge in London on March 17.
It is the latest European match to be switched as a result of the Covid-19 pandemic.
The Spanish government on Tuesday extended a ban on flights from Britain, Brazil and South Africa from February 16 to March 2, in an attempt to stem the spread of new variants of the virus.
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Only legal residents or nationals of Spain and the neighbouring micro-state of Andorra are currently allowed in on flights from those countries.
It is the fourth time that Spain has extended its restrictions on arrivals from Britain, which were initially put in place at the end of December.
jw/td