20 things you should know about Breast Cancer

As part of efforts to promote the October 1-31 Breast Cancer Awareness Month, here are 20 facts you should know about Breast Cancer.

Ask any woman what disease she's most afraid of, and chances are she'll say breast cancer. "Almost everyone knows someone who did everything 'right' and still got breast cancer," says Victoria Seewaldt, MD, who is co-leader of the breast and ovarian cancer program at the Duke University Comprehensive Cancer Center. "That can make women feel like they have no control."

While you can't control your genes, there are powerful steps you can take to protect yourself. But experts say there's a lot of confusion about what really matters. Here's what they want you to know about…

1. Clinical breast exams are as important as mammograms. Mammograms starting at age 40 are crucial (get them earlier if you have a family history of the disease), but they're an imperfect screening tool, especially in women who have dense breasts. That's why an annual clinical breast exam from a doctor is a must. "This is especially important for detecting inflammatory breast cancer [a rare but aggressive type that can make the breast swollen and red], which often doesn't show up on mammograms," explains Katherine B. Lee, MD, a breast specialist at the Cleveland Clinic Breast Center. On the other hand, ductal carcinoma in situ (DCIS), the earliest form of breast cancer, which is limited to the milk ducts, is most often found on mammograms. So both screenings are equally important.

2. Breast self-exams really can help. It's good to do them at the same time every month, but don't stress out if you don't have them penciled into your planner. What self-exams do is help you become familiar with what's "normal" for your breasts. So when something's off, you'll know and can bring it to your doctor's attention. After all, you know your body better than any doctor does.


3. Don't panic if you get called for a mammogram "redo" or have calcifications. Many women over 40 have calcium deposits (calcifications) in their breasts, and most of them are benign. "It's part of the aging process of the tissue," explains Dr. Lee. These can show up as white spots on a mammogram—they tend to be harmless if they're large, coarse, solitary spots but suspicious if the tiny flecks cluster together in a linear pattern. Most radiologists can distinguish between the two, and only the suspicious ones warrant a biopsy. Although the period between the initial and follow-up mammograms can be anxiety-filled— a common reason some women delay their followups, says research at the Dana-Farber Cancer Institute in Boston—most of the time the callback turns out to be nothing.

4. Active women are less likely to develop and die from breast cancer. Regular exercise has consistently been associated with a lower risk of breast cancer. "Any type of exercise is likely to help by lowering estrogen levels," Dr. Seewaldt explains. What's more, a new study from the University of South Carolina suggests that women with high aerobic fitness levels (based on their endurance on a treadmill exercise test) have a 55% lower chance of dying from breast cancer than their less-fit peers. So get moving!

5. Get your folate. While experts say that an overall healthy diet may help prevent breast cancer, a growing body of research suggests that getting enough of the B vitamin folate (in leafy green vegetables, beans and fortified cereals) may help mitigate the increased risk associated with drinking alcohol. (Having two or more drinks a day ups breast cancer risk by about 25%.) Go easy on the alcohol, but "if you have one drink daily, getting plenty of folate from your diet or a multivitamin may help," says Claudine Isaacs, MD, director of the clinical breast cancer program at Georgetown University Medical Center.

6. Being overweight is riskiest after menopause. Of course, staying at a healthy weight throughout your life lowers your risk of just about everything, including heart disease, type 2 diabetes and arthritis. But when it comes to breast cancer, it's the postmenopause pounds that are particularly dangerous. "In postmenopausal women, one of the most significant sources of estrogen comes from body fat," explains Dr. Isaacs. "So if you're overweight, you have higher amounts of circulating estrogen, which could stimulate breast cancer growth." And it doesn't take much: Losing even 10 pounds may help lower your risk.

8. Lumpy breasts don't mean a higher risk of cancer. Many women have cysts in their breasts that come and go throughout their menstrual cycles (which are also known as fibrocystic changes). Feeling any kind of lump or bump can be scary, but these types of cysts don't typically lead to cancer, Dr. Seewaldt points out. Still, it's especially important for women who have fibrocystic breasts to do breast self-exams and get annual clinical breast exams so any lump that is out of the ordinary can be thoroughly checked out.


9. Pain isn't usually a sign of breast cancer. If you have pain in one or both breasts, rest assured: It's probably due to hormonal changes, a benign cyst, a ligament strain or another condition, says Dr. Isaacs. More common warning signs of breast cancer include a palpable lump, a change in the size or shape of the breast, puckering of the skin, nipple changes (like scaling or discharge), or increased warmth—changes you should bring to your doctor's attention ASAP.

10. Women with very dense breasts are four times more likely to develop breast cancer."When breast tissue is dense, the cells grow and multiply at a faster rate, which means there's more of a chance for some to become abnormal or cancerous," explains Dr. Lee. Ask your doctor if you have dense breasts; she should be able to tell you based on a clinical breast exam and a mammogram. Since mammograms aren't as effective at detecting cancer in very dense breasts, if yours fall into this category you may benefit from getting regular MRI scans or ultrasounds plus mammograms.

11. Breast cancer risk is not 1 in 8 for all women. That stat applies to lifetime risk, assuming you live to 85 or beyond. At age 40, the average woman has a 1 in 69 chance of getting breast cancer in the next 10 years; at 50, the risk rises to 1 in 42; at 60, it's 1 in 29; and at 70, it's 1 in 27. Which means that statistically speaking, women are at most risk for breast cancer in their 70s and 80s—but that's when breast cancer has the highest cure rate because women in that age group usually get a less aggressive and more treatable form of the disease, says Dr. Seewaldt.

12. A family history doesn't mean you'll definitely get it. Only about 20% to 30% of people who develop breast cancer have a family history of the disease, and an even smaller number—5% to 10%—carry a BRCA1 or 2 mutation (the so-called breast cancer genes), Dr. Isaacs explains. So rest assured: Biology isn't destiny.

13. If it's caught very early, breast cancer has more than a 90% survival rate in the U.S."The majority of women who get breast cancer in this country don't die from it," says Powel Brown, MD, PhD, a medical oncologist at the Baylor College of Medicine in Houston and a member of the scientific advisory board for Susan G. Komen for the Cure. At stage 0 (which means the cancer's confined to the milk ducts) and stage I (a tumor is 2 cm or less and hasn't spread beyond the breast), the five-year survival rate is now 100%, according to the American Cancer Society (ACS). Five years may not sound like much, but "if you get to the five-year benchmark without a recurrence, your prognosis for leading a long, healthy life is good," Dr. Seewaldt says. At stage II (the tumor is between 2 and 5 cm or the cancer has spread to one to three lymph nodes), the five-year survival rate is 86%. Thanks to better screening, most breast cancers in the U.S. are now caught in the early stages.


14. Many factors affect your risk. Family history isn't the only thing that matters: Other factors come into play, including when you first got your period, if or when you have children and how active you are. Discuss all the details of your lifestyle and medical history with your doctor so she can make sure you're getting the right screenings at the right time.

15. A father or brother with prostate or colon cancer can raise your risk. These are signs of possible BRCA1 or 2 mutations, Dr. Lee says. These gene mutations can run on your dad's side, so be sure to ask if any of his female relatives had breast or ovarian cancer.

16. Get an MRI and a mammogram. Doing both will increase the odds of picking up small tumors in women who are at high risk (if you have a strong family history of breast and ovarian cancer and carry the BRCA1 or 2 mutation). However, an MRI should only be ordered under the care of a breast specialist, says Anne Wallace, MD, a team leader of the Moores Cancer Center breast program at the University of California, San Diego.

17. If you have the BRCA1 or 2 mutations, removing your ovaries lowers your risk by nearly 50%. "Your ovaries produce hormones, so taking them out changes the hormonal mix," explains Dahlia Sataloff, MD, a clinical professor of surgery at the University of Pennsylvania and director of the Integrated Breast Center at Pennsylvania Hospital in Philadelphia.

18. Taking certain medications can help. Tamoxifen and raloxifene are drugs that can block estrogen's ability to promote breast cancer. They lower the chances of developing the disease by about 50% in women who carry the BRCA1 or 2 mutation, says Dr. Brown. "These medications can be used for five years and the risk reduction continues for 10 years after stopping them. Yet most women who are candidates for the drugs aren't taking them." Of course, there are side effects: Both drugs can worsen hot flashes, and tamoxifen increases the risk of uterine cancer. But for some women, those risks are considered worth the benefit. "These meds are much less invasive than using prophylactic mastectomy [having both of your breasts removed before there's any cancer] to reduce your risk," says Dr. Brown.


19. Breast cancer is not a single disease. What's helped doctors and scientists develop more effective treatments is realizing that there are different types of breast cancer with different causes. Among the primary ones: estrogen-receptor-positive breast cancers, whose growth is fueled by the hormone estrogen; HER-2-positive breast cancers, which contain a protein called HER-2/neu; and triple-negative breast cancers, which don't have receptors for estrogen, progesterone or HER-2.

20. Chemotherapy isn't always a given. These days, doctors do genetic profiling on a breast cancer tumor (using advanced tests like the Oncotype DX or MammaPrint) to gauge a woman's risk of a recurrence. If chances are low, doctors may not advise chemotherapy. "We're being more selective about using chemotherapy to help women avoid unnecessary toxicity and having to go through unnecessary suffering," says Dr. Wallace.



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