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The renowned physician died on Friday morning at the University of Ghana Medical Centre in Accra.
Prof. Plange-Rhule had been on admission at the hospital for some time, having battled a short illness.
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The Graphic Online reports that he had been referred to the Centre from private care and was admitted to the Intensive Care Unit with a critical condition.
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Prof Jacob Plange-Rhule passes on
The report added that although he showed great signs of recovering, he suddenly suffered a relapse on Friday morning, which eventually led to his death.