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Emmanuel Agyemang Badu created an early assist but it was not enough as Udinese fell 2-1 at home to Sassuolo on Sunday afternoon in Serie A.
It was the Ghana international's third assist of the season in his 17th appearances.
But it was Gregoire Defrel who came off the bench and transformed the match, bagging a brace as Sassuolo fought back to victory.
It was a perfect supersub performance from the French striker, who first equalised with his second touch – a cushioned volley – and then curled in the winning goal.
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Udinese had taken an early lead through Seko Fofana, so were jeered off the field by their fans.
The game finished with Udinese unable to equalise as they remain on 29 points and in 13th place while Sassuolo move one point above them with 30 points.