The Arsenal midfielder will captain the Black Stars in the absence of regular skipper Andre Ayew, who is not part of the matchday squad.
The veteran forward and Southampton defender Mohammed Salisu are the only two players excluded from the matchday squad by Chris Hughton.
Reports suggest the technical team of the Black Stars decided to leave the pair out of the matchday squad as a precaution.
Meanwhile, Lawrence Ati Zigi, however, maintains his position in post, having been Ghana’s starting goalkeeper at the Qatar 2022 World Cup.
He is flanked by a defensive quartet of Denis Odoi, Gideon Mensah, Alexander Djiku and Daniel Amartey as Mohammed Salisu sits out due to injury.
Thomas Partey also starts as captain of the side and will be partnered in midfield by the returning Edmund Addo.
Premier League duo Jordan Ayew and Kamaldeen Sulemana are tasked with providing width on either flank.
In-form Ajax star Mohammed Kudus has been deployed as a no.10, with Athletic Bilbao’s Inaki Williams leading the line as lone striker.
The Black Stars will host Angola in an hours time at the Baba Yara Stadium as they aim to take control of Group E of the qualifying.
The fixture is the first of a double-header in the March international window, with the return leg slated for Luanda in four days time.
See Ghana’s starting XI against Angola below:
Lawrence Ati Zigi
Denis Odoi
Gideon Mensah
Daniel Amartey
Alexander Djiku
Edmund Addo
Thomas Partey
Kamaldeen Sulemana
Jordan Ayew
Mohammed Kudus
Inaki Williams