Sally Pearson takes a tumble as Justin Gatlin impresses again
Pearson, the women's 100 metre hurdles Olympic champion, took a tumble just past the halfway point of Thursday's race and was left clutching her wrist in pain.
Athletics Australia later confirmed the Australian runner would need surgery.
Sharika Nelvis of the United States took advantage of Pearson's misfortune in a race that saw two others fall to take victory in a personal best time of 12.52 seconds.
But it was her compatriot Gatlin who grabbed the headlines again with another stunning performance, winning the 100m in a meet record time of 9.75secs having run a 9.74 in the opening event of the Diamond League season last month.
Two-time 100m Olympic gold medallist Shelly-Ann Fraser-Pryce withdrew from the 200m due to a problem sustained in the warm-up, leaving Jessica Tarmoh to triumph in 22.77secs.
Francena McCorory won the women's 400m, while Jenny Simpson set a world-lead time of three minutes, 59.31secs in her 1500m victory.
Mohammed Aman was successful in the men's 800m, setting a world-lead mark of one minute, 43.56secs and Jonny Dutch beat Michael Tinsley to the line in the 400m hurdles.
In the two long-distance races Yomif Kejelcha (12:58.39) recorded a world-lead time in the men's 5000m and Hyvin Kiyeng (9:15.08) did the same in the women's 3000m steeplechase.
World record holder Renaud Lavillenie unsurprisingly claimed victory in the pole vault, with runner-up Thiago Braz setting a South American record of 5.86m.
Ruth Beitia's world-lead effort of 2.00m saw her win the high jump and Pedro Pablo Pichardo posted a meet record of 17.96m in his men's triple jump triumph.
Meanwhile, David Storl won the men's shot put, Darya Klishina triumphed in the women's long jump, Sandra Perkovic tasted success in the discus and Vitezslav Vesely emerged victorious in the men's javelin.