The body of the woman was found in a pool of blood at the Peace Gardens guesthouse compound.
It is not yet clear what caused the attack, but Accra-based Joy FM reports that some land guards have recently been attacking some residents in the area.
A neighbour, who arrived at the guesthouse compound after the attack, said he heard some unusual noises and rushed to the scene.
According to him, he found the lady lying naked in a pool of blood.
He said the woman was able to narrate what happened to her before giving up the ghost, saying that she was raped and shot later.