Godfred Donsah was on target for Bologna in their 3-2 win over Sampdoria in the Italian Serie A on Sunday.
But just after the hour mark, Donsah picked up a knock and retired from the match making way for Luca Rizzo.
Vincenzo Montella's men hit back in the second half, however, with strikes from Luis Muriel and Joaquin Correa threatening to deny Bologna the chance to climb into the top half of the Serie A table.
But 24-year-old Destro stepped up to convert an 86th-minute penalty after former Sunderland midfielder Ricky Alvarez had handled the ball in the Samp box.
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The game ended 3-2 in favour of Godfredn Donsah's Bologna.