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Things did not look promising when Harrison pulled up against the Cincinnati Reds on Saturday.
The news is about as bad as the Pirates feared.
The team announced on Monday that Harrison will miss the rest of the season with a strained right groin.
Given the recovery time of four to six weeks, Harrison's regular season is certainly done, but he left open the slim possibility he could return if the Pirates advance deep into the postseason.
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However, the reeling Pirates appear unlikely to even qualify for the playoffs.
While they were only a half game behind the second wildcard spot entering August 29, the Pirates have lost 11 of 13 games and are now six behind in the playoff race with 21 games to play.
Sean Rodriguez and Adam Frazier will likely split time at second in Harrison's absence.