The 24-year player born to Ghanaian parents in France joined Caen in 2013 from Monaco and has now moved away from his country of birth to Belgium to seek new adventure.
The 5-year contract will keep him at the Constant Vanden Stock until 2021.
Appiah is yet to commit his future to either France or Ghana, but has represented the French at youth levels.
Dennis Appiah plays as a defensive midfielder and is also capable of playing in defence as a central defender.