In the 76th minute, Medeama were reduced to ten men after goalkeeper Eric Ofori Antwi was sent off for handling the ball outside the box.
However, it was ten men that secured full spoils thanks to a stupendous strike by Kwesi Donsu in added time.
The victory means Medeama have taken control as they occupy top spot with 23 points.
While Aduana are in the drop zone but have four games in hand.
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