The Ghanaian side went into the game with a calculated defensive strategy which yielded dividend.
Ahly Shandi saw plenty of the ball as they dominated play, but the Mauve and Yellows who were resolute at the back relied on counter-attack.
The closest the home side came, Muntari Tagoe who had a wonderful game came to the rescue of the Ghanaian side.
Despite pressure mounted by Ahly Shandi, Tom Strand never abandoned his strategy as they kept their shape with the hosts getting frustrated during the course of the game.
The Ghanaian side had their moments in the 70th minute, but Abass Mohammed failed to convert that chance.
With the game ending scoreless, the second leg will come off on Wednesday 20th April, 2016 at the Essipong Sports Stadium.
Medeama starting X1 against Al Shandy: Munatri Tagoe, Samuel Adade, Moses Sarpong, Daniel Amoah, Paul Aidoo, Malik Akowuah, Kwame Boahene, Akwasi Donsu, Eric Kwakwa, Samuel Bio, Abass Mohammed.