The Ghana International opened the scoring as early as the 7th minute, after drilling through the Bulls defence as Columbus Crew went on to win 3-2 in the MLS.
The gold and Blacks put their road doldrums behind them in a big way, scoring three times in the first thirty minutes at the Red Bull Arena.
Patrick Mullins doubled the advantage in the 24th minute, racing onto a ball played into space by Harrison Afful before slotting low inside the far post for his first Crew SC goal.
Columbus made it 3-0 in the 31st minute when Sean Davis headed a Santos corner kick into his own goal at the near post.
Chris Armas made a double switch at halftime, bringing on Bradley Wright-Phillips and Kaku and the Red Bulls (13-6-2) rallied to cut their deficit to one on a Mensah own goal and Danny Royer’s sixth of the season.