The Ghana striker was brought on for French striker Ludovic Ajorque in the 85th minute.
Ajorque opened the scoring for Thierry Laurey’s men in the 40th minute after receiving a sumptuous assist from Lucien Kevin Zohi.
Adrien Thomasson and Stefan Mitrovic then increased the lead before Stevan Jovetic scored a consolatory goal for Monaco late into the game
The win puts Strasbourg 7th on the league log after gathering 30 points from 21 games, one point behind 6th placed Lille.