Marco Estrada pitched eight strong innings and Edwin Encarnacion had two RBIs as the Blue Jays beat the New York Yankees 4-2.
Toronto have won five of their past six matches to improve to 27-26 after a slow start to the season.
Matt Harvey looked close to his best as he pitched seven innings in the New York Mets' 1-0 win over the Chicago White Sox.
After a slow start, Harvey gave up just two hits and struck out six in his latest outing to improve to 4-7.
The Chicago Cubs' bullpen led them past the Los Angeles Dodgers 2-0, the Seattle Mariners claimed a 9-3 win over the San Diego Padres and Collin McHugh pitched a complete game in the Houston Astros' 8-3 victory against the Arizona Diamondbacks.
The Atlanta Braves held on to beat the San Francisco Giants 5-3, a five-run eighth saw the Los Angeles Angels beat the Detroit Tigers 5-1 and the Kansas City Royals were 6-2 victors against the Tampa Bay Rays.
The Cincinnati Reds battled past the Colorado Rockies 11-8 and the Oakland Athletics overcame the Minnesota Twins 3-2.
Matt Holliday and Matt Carpenter guided the St Louis Cardinals past the Milwaukee Brewers 6-0 and the Boston Red Sox were too good for the Baltimore Orioles 7-2.
The Pittsburgh Pirates shut out the Miami Marlins 10-0, the Washington Nationals edged the Philadelphia Phillies 4-3 and the Texas Rangers crushed the Cleveland Indians 9-2.
DUVALL HOMERS TWICE
Outfielder Adam Duvall enjoyed his first career two-homer day as the Reds blasted five long balls in a slugfest with the Rockies. For Duvall, it was numbers 12 and 13 this season. POLANCO HITS SLAM
Pirates outfielder Gregory Polanco capped off a five-run inning against the Marlins with an absolute blast of a grand slam, the first of his career. Outfielder Cole Gillespie barely even attempted to chase down the fly ball. That is when you know it is gone.
MAZARA BLASTS 453-FOOTER
With his 453-foot, three-run homer against the Indians, Texas Rangers outfielder Nomar Mazara joins Giancarlo Stanton and Carlos Correa as the only players with multiple 450-foot home runs this season. COLE, FERNANDEZ DO BATTLE
A pair of Cy Young Award candidates to begin the season square off in Miami as the Pirates' Gerrit Cole (5-3, 2.53 ERA) and Marlins' Jose Fernandez (7-2, 2.82) do battle. For Fernandez, he looks to continue his career dominance at Marlins Park, where the right-hander is 21-1 with a 1.64 ERA in his young career.