The agreement, filed in a California federal court, was focused on travel, hotel accommodations, match venues and staffing, while setting up an appeal from players over a court ruling last May that rejected many of their claims for equal pay to male players in a wage discrimination lawsuit.
US Soccer president Cindy Cone, who took over the post earlier this year, called the settlement "an important and welcomed moment for US Soccer and the women's national team players".
"I believe our approach helped us reach this agreement and demonstrates the commitment of US Soccer's new leadership to find a new way forward with the USWNT. This settlement is good news for everyone and I believe will serve as a springboard for continued progress."
Terms of the deal would begin immediately but would not address past actions or involve payments to the women, whose litigation could lead to millions of dollars in back pay if successful.
Cone said she hoped the "positive step forward" would lead to the women's players "accepting our standing offer to discuss contract options".
Cone, a former US women's player, said she was "committed to equality" between the US men's and women's teams, adding: "My goal is, and has always been, to come to a resolution on all equal pay matters and inspire a new era of collaboration, partnership and trust."
The US won its fourth Women's World Cup title in France last year.